Dopamine agonists restore cortical plasticity in patients with idiopathic restless legs syndrome
Identifieur interne : 002349 ( Main/Exploration ); précédent : 002348; suivant : 002350Dopamine agonists restore cortical plasticity in patients with idiopathic restless legs syndrome
Auteurs : Vincenzo Rizzo [Italie] ; Irene Aric [Italie] ; Claudia Mastroeni [Italie] ; Francesca Morgante [Italie] ; Giovanna Liotta [Italie] ; Paolo Girlanda [Italie] ; Rosalia Silvestri [Italie] ; Angelo Quartarone [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-04-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Aged, Analysis of Variance, Case-Control Studies, Dopamine Agonists (pharmacology), Dopamine Agonists (therapeutic use), Dopamine agonist, Electric Stimulation (methods), Evoked Potentials, Motor (drug effects), Evoked Potentials, Motor (physiology), Female, Human, Humans, Idiopathic, Male, Median Nerve (physiology), Middle Aged, Motor Cortex (drug effects), Motor Cortex (physiopathology), Nervous system diseases, Neuronal Plasticity (drug effects), Neuronal Plasticity (physiology), Plasticity, Restless Legs Syndrome (drug therapy), Restless Legs Syndrome (pathology), Restless legs syndrome, Time Factors, Transcranial Magnetic Stimulation, Transcranial magnetic stimulation, associative plasticity, restless legs syndrome, transcranial magnetic stimulation.
- MESH :
- chemical , pharmacology : Dopamine Agonists.
- chemical , therapeutic use : Dopamine Agonists.
- drug effects : Evoked Potentials, Motor, Motor Cortex, Neuronal Plasticity.
- drug therapy : Restless Legs Syndrome.
- methods : Electric Stimulation.
- pathology : Restless Legs Syndrome.
- physiology : Evoked Potentials, Motor, Median Nerve, Neuronal Plasticity.
- physiopathology : Motor Cortex.
- Adult, Aged, Analysis of Variance, Case-Control Studies, Female, Humans, Male, Middle Aged, Time Factors, Transcranial Magnetic Stimulation.
Abstract
In the present work, we aimed at assessing whether patients with idiopathic restless legs syndrome (RLS) showed alterations of sensory‐motor plasticity, an indirect probe for motor learning, within the motor cortex (M1). Previous findings suggest that learning in human M1 occurs through LTP‐like mechanisms. To test our hypothesis, we employed the paired associative stimulation (PAS) protocol by transcranial magnetic stimulation (TMS), which is able to induce LTP‐like effects in the motor cortex of normal subjects. Twelve patients with idiopathic RLS and 10 age‐ and sex‐matched control subjects were recruited. PAS protocol consisted of 0.05 Hz electrical median nerve stimulation (90 stimuli), paired with 0.05 Hz TMS (90 stimuli) over the hot spot for stimulating the abductor pollicis brevis (APB) muscle given 25 milliseconds after the onset of the electrical stimulus. Corticospinal excitability recorded in APB muscle, as indexed by MEP obtained after single stimulus, was tested before and up to 30 minutes after PAS protocol. Eight of 12 patients were studied before and after 4 weeks of dopaminergic treatment. PAS protocol increased significantly corticospinal excitability as long as 30 minutes in healthy subjects. On the contrary, PAS protocol did not change the amplitude of MEPs in patients with idiopathic RLS without treatment. PAS associative plasticity was restored after 4 weeks of dopaminergic treatment. Our data demonstrated that associative sensory‐motor plasticity, an indirect probe for motor learning, is impaired in idiopathic RLS patients but may be reverted to normal after dopaminergic treatment. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22436
Affiliations:
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uniqKey="Mastroeni C" first="Claudia" last="Mastroeni">Claudia Mastroeni</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina, Messina</wicri:regionArea><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina, Messina</wicri:regionArea><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Liotta, Giovanna" sort="Liotta, Giovanna" uniqKey="Liotta G" first="Giovanna" last="Liotta">Giovanna Liotta</name><affiliation wicri:level="1"><country 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Messina</wicri:regionArea><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Quartarone, Angelo" sort="Quartarone, Angelo" uniqKey="Quartarone A" first="Angelo" last="Quartarone">Angelo Quartarone</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurosciences, Psychiatry, and Anaesthesiological Science, University of Messina, Messina</wicri:regionArea><wicri:noRegion>Messina</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-04-15">2009-04-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="710">710</biblScope><biblScope unit="page" to="715">715</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C67B0D4E78A964AEEDFBD7FB93ABCBC426EEB772</idno><idno type="DOI">10.1002/mds.22436</idno><idno type="ArticleID">MDS22436</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Dopamine Agonists (pharmacology)</term><term>Dopamine Agonists (therapeutic use)</term><term>Dopamine agonist</term><term>Electric Stimulation (methods)</term><term>Evoked Potentials, Motor (drug effects)</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Human</term><term>Humans</term><term>Idiopathic</term><term>Male</term><term>Median Nerve (physiology)</term><term>Middle Aged</term><term>Motor Cortex (drug effects)</term><term>Motor Cortex (physiopathology)</term><term>Nervous system diseases</term><term>Neuronal Plasticity (drug effects)</term><term>Neuronal Plasticity (physiology)</term><term>Plasticity</term><term>Restless Legs Syndrome (drug therapy)</term><term>Restless Legs Syndrome (pathology)</term><term>Restless legs syndrome</term><term>Time Factors</term><term>Transcranial Magnetic Stimulation</term><term>Transcranial magnetic stimulation</term><term>associative plasticity</term><term>restless legs syndrome</term><term>transcranial magnetic stimulation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Evoked Potentials, Motor</term><term>Motor Cortex</term><term>Neuronal Plasticity</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Evoked Potentials, Motor</term><term>Median Nerve</term><term>Neuronal Plasticity</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Time Factors</term><term>Transcranial Magnetic Stimulation</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Homme</term><term>Idiopathique</term><term>Pathologie du système nerveux</term><term>Plasticité</term><term>Stimulant dopaminergique</term><term>Stimulation magnétique transcrânienne</term><term>Syndrome des jambes sans repos</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the present work, we aimed at assessing whether patients with idiopathic restless legs syndrome (RLS) showed alterations of sensory‐motor plasticity, an indirect probe for motor learning, within the motor cortex (M1). Previous findings suggest that learning in human M1 occurs through LTP‐like mechanisms. To test our hypothesis, we employed the paired associative stimulation (PAS) protocol by transcranial magnetic stimulation (TMS), which is able to induce LTP‐like effects in the motor cortex of normal subjects. Twelve patients with idiopathic RLS and 10 age‐ and sex‐matched control subjects were recruited. PAS protocol consisted of 0.05 Hz electrical median nerve stimulation (90 stimuli), paired with 0.05 Hz TMS (90 stimuli) over the hot spot for stimulating the abductor pollicis brevis (APB) muscle given 25 milliseconds after the onset of the electrical stimulus. Corticospinal excitability recorded in APB muscle, as indexed by MEP obtained after single stimulus, was tested before and up to 30 minutes after PAS protocol. Eight of 12 patients were studied before and after 4 weeks of dopaminergic treatment. PAS protocol increased significantly corticospinal excitability as long as 30 minutes in healthy subjects. On the contrary, PAS protocol did not change the amplitude of MEPs in patients with idiopathic RLS without treatment. PAS associative plasticity was restored after 4 weeks of dopaminergic treatment. Our data demonstrated that associative sensory‐motor plasticity, an indirect probe for motor learning, is impaired in idiopathic RLS patients but may be reverted to normal after dopaminergic treatment. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Rizzo, Vincenzo" sort="Rizzo, Vincenzo" uniqKey="Rizzo V" first="Vincenzo" last="Rizzo">Vincenzo Rizzo</name></noRegion><name sortKey="Aric, Irene" sort="Aric, Irene" uniqKey="Aric I" first="Irene" last="Aric">Irene Aric</name><name sortKey="Girlanda, Paolo" sort="Girlanda, Paolo" uniqKey="Girlanda P" first="Paolo" last="Girlanda">Paolo Girlanda</name><name sortKey="Liotta, Giovanna" sort="Liotta, Giovanna" uniqKey="Liotta G" first="Giovanna" last="Liotta">Giovanna Liotta</name><name sortKey="Mastroeni, Claudia" sort="Mastroeni, Claudia" uniqKey="Mastroeni C" first="Claudia" last="Mastroeni">Claudia Mastroeni</name><name sortKey="Morgante, Francesca" sort="Morgante, Francesca" uniqKey="Morgante F" first="Francesca" last="Morgante">Francesca Morgante</name><name sortKey="Quartarone, Angelo" sort="Quartarone, Angelo" uniqKey="Quartarone A" first="Angelo" last="Quartarone">Angelo Quartarone</name><name sortKey="Silvestri, Rosalia" sort="Silvestri, Rosalia" uniqKey="Silvestri R" first="Rosalia" last="Silvestri">Rosalia Silvestri</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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